Peculiarities of cytolytic syndrome development with associated injury of the abdominal organs and massive blood loss in the experiment

The function of the organs responsible for detoxification processes, in particular liver, deserves a special role conditions combined trauma. It is proved that ischemia-reperfusion limb caused by imposition tourniquet, cause significant toxemia. Under such conditions, it becomes clear may be impaired, especially against background blunt trauma to abdominal complicated massive bleeding. Changes liver are indicated markers cytolytic syndrome. However, there no understanding how ischemia - reperfusion affects development syndrome.Objective research: study effect blood loss associated with on syndrome indicators case injury organs. Materials and methods. 100 mature albino male Wistar rats body weight 190-220 grams kept standard vivarium forage were used experiment. animals divided into control 3 research groups (containing 10 each). Arresting bleeding tourniquet was applied proximally lower limbs from first group 120 minutes under thiopental-sodium anesthesia (40 mg/kg-1), which ischemic-reperfusion. Closed simulated means delivering two dosed blows region cavity second group; cutting femoral vessels bloodletting 25 30 % circulating volume group. Injuries third received without formation any injuries. With aim determine alterations activity enzymes – ALT AST determined unified method. removed experiment total heart.Results. Analysis results found develops irrespective kind injuries simulated. Thus, even during day post-traumatic period increases clearly registered all three groups. Further destruction cellular membranes till 3rd day, manifested considerable increase serum. This process continues 7th day. A tendency decrease observed only 1st Comparison 2nd within time interval enables understand application tourniquets closed deteriorates processes.Conclusions: Simulated occurrence processes possessing develop early signs traumatic disease. Ischemic-reperfusion accelerates considerably systemic changes hypovolemic shock, parameters becoming higher than end